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[杏仁核复合体对大鼠获取食物条件反应的单胺能效应的药理学分析]

[Pharmacological analysis of monoaminergic effects of the amygdaloid complex on the food-procuring conditioned reaction of rats].

作者信息

Talalaenko A N

出版信息

Farmakol Toksikol. 1976 Sep-Oct;39(5):525-9.

PMID:195835
Abstract

The produced by microinjections of dopamine, norepinephrine, serotonin and glutamic acid into the dorsomedial divisions of the tonsil on the food-procuring conditioned reaction of rats was studied. All of the studied substances were found to lengthen the latent time of the conditioned food reaction, the number of food-procuring movements and the scope of the reflex increasing under the effect of dopamine and serotonin, but diminishing following introduction of norepinephrine and glutamic acid. The dopamine effects materialize through the medium of the tonsil neuron receptors, which are sensitive of haloperidol or chloropromazine, and those serotnin--through D-serotonin-sensitive neuron system structures of the amygdaloid complex. The inhibitory effects of norepinephrine are not of an elective nature, for they correlate with the depression of the spontaneous motor activity of the rats. The modulating influence of glutamic acid on the food-procuring conditioned reflex reaction of the rats is not associated with the action on the dopamine, or serotonin-reactive neuron systems of the dorso-medial tonsil.

摘要

研究了向大鼠扁桃体背内侧部微量注射多巴胺、去甲肾上腺素、5-羟色胺和谷氨酸对获取食物的条件反应的影响。结果发现,所有研究物质均能延长条件性食物反应的潜伏期,多巴胺和5-羟色胺作用下获取食物动作的数量及反射范围增加,而去甲肾上腺素和谷氨酸注射后则减少。多巴胺的作用通过对氟哌啶醇或氯丙嗪敏感的扁桃体神经元受体实现,5-羟色胺的作用则通过杏仁复合体中对D-5-羟色胺敏感的神经元系统结构实现。去甲肾上腺素的抑制作用并非具有选择性,因为它们与大鼠自发运动活动的抑制相关。谷氨酸对大鼠获取食物的条件反射反应的调节作用与对背内侧扁桃体的多巴胺或5-羟色胺反应性神经元系统的作用无关。

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