Kovalev G V, Spasov A A
Farmakol Toksikol. 1976 Sep-Oct;39(5):574-7.
Tests staged on rats showed the hypertensive drug ethyron (ethylisothiuronium) to intensify the activity of the oxidative system and pentose cycle in the myocardium, to increase the pyruvate content, raise the redox potential of the lactate-pyruvate potential, to reduce the amount of lactate, heighten the activity of the lactate, malate dehydrogenases, glucose-6-phosphate and cytochrome-c-oxydase. In an isolated spontaneously contracting atrium ethyron abolished the suppressing effect of carbohydrate metabolism inhibitors (sodium fluoride and copper sulphate) on the intensity and frequency of contractions.
在大鼠身上进行的实验表明，降压药乙磺隆（乙基异硫脲）可增强心肌中氧化系统和戊糖循环的活性，增加丙酮酸含量，提高乳酸 - 丙酮酸电位的氧化还原电位，减少乳酸量，提高乳酸脱氢酶、苹果酸脱氢酶、葡萄糖 - 6 - 磷酸脱氢酶和细胞色素 - c - 氧化酶的活性。在离体自发收缩的心房中，乙磺隆消除了碳水化合物代谢抑制剂（氟化钠和硫酸铜）对收缩强度和频率的抑制作用。
