AMPK 激活的清晰视图。
A crystallized view of AMPK activation.
作者信息
Young Lawrence H
机构信息
Section of Cardiovascular Medicine, Departments of Internal Medicine and Physiology, Yale University School of Medicine, New Haven, CT 06520, USA.
出版信息
Cell Metab. 2009 Jul;10(1):5-6. doi: 10.1016/j.cmet.2009.06.008.
PMID:19583947
Abstract
AMP-activated protein kinase (AMPK) is a key metabolic regulator. Recent work (Chen et al., 2009) elucidates the structural interaction between the autoinhibitory sequence and the kinase domain of the AMPK catalytic subunit. Enhanced understanding of the molecular mechanics of AMPK activation might lead to novel therapeutic approaches.
摘要
AMP激活的蛋白激酶（AMPK）是一种关键的代谢调节因子。近期的研究工作（Chen等人，2009年）阐明了AMPK催化亚基的自抑制序列与激酶结构域之间的结构相互作用。对AMPK激活分子机制的深入理解可能会带来新的治疗方法。
Zotero 插件