一只拳师犬脂肪瘤内的皮肤肥大细胞瘤。

Cutaneous mast cell tumour within a lipoma in a boxer.

作者信息

Jakab Csaba, Szász Attila Marcell, Kulka Janina, Schaff Zsuzsa, Rusvai Miklós, Németh Tibor, Gálfi Péter

机构信息

Szent István University, Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Medicine, István utca 2 H-1078 Budapest, Hungary.

出版信息

Acta Vet Hung. 2009 Jun;57(2):263-74. doi: 10.1556/AVet.57.2009.2.7.

DOI:10.1556/AVet.57.2009.2.7

PMID:19584039

Abstract

This report describes a case of a canine cutaneous grade I mast cell tumour which developed within a lipoma in the right axillar region of an 8-year-old male Boxer. Immunohistologically, the neoplastic mast cells were positive for serotonin, CD45 vimentin and p53, and negative for lysozyme, CD3 and CD79a expression. The proliferation index of the mast cell tumour based on the Ki-67 antigen was 6.1%. Between the benign neoplastic lipocytes and mastocytoma tumour cells intratumoural microvessels were detected by immunohistochemical staining using CD31 and claudin-5 as markers for vascular endothelium.

摘要

本报告描述了一例8岁雄性拳师犬右腋窝区脂肪瘤内发生的I级皮肤肥大细胞瘤病例。免疫组织化学检查显示，肿瘤性肥大细胞血清素、CD45、波形蛋白和p53呈阳性，溶菌酶、CD3和CD79a表达呈阴性。基于Ki-67抗原的肥大细胞瘤增殖指数为6.1%。使用CD31和claudin-5作为血管内皮标志物进行免疫组织化学染色，在良性肿瘤性脂肪细胞和肥大细胞瘤肿瘤细胞之间检测到瘤内微血管。