Berlato D, Murphy S, Monti P, Stewart J, Newton J R, Flindall A, Maglennon G A
Centre for Small Animal Studies, Animal Heath Trust, Newmarket, UK.
Central Diagnostic Services, The Queen's Veterinary School Hospital, University of Cambridge, Cambridge, UK.
Vet Comp Oncol. 2015 Jun;13(2):143-50. doi: 10.1111/vco.12029. Epub 2013 Mar 12.
Proliferation markers are commonly used for prognostication of mast cell tumours. The aim of the study is to compare the relative abilities of Ki67 and mitotic index to predict survival in the same cohort of dogs with cutaneous MCTs. Histological grade, mitotic index and Ki67 index were performed in all samples and clinical information was obtained by a follow-up questionnaire. Ninety-five dogs were included in the study with a median follow-up of 1145 days. Survival times varied significantly between categories of histological grade, mitotic index and Ki67 index. Multivariable analyses showed that the risk of dying due to MCT was similar in dogs with increased Ki67 index [hazard ratio, HR: 3.0 (95% CI 1.3-6.8)] or increased mitotic index [HR: 2.7 (95% CI 1.1-6.5)]. In conclusion, both mitotic index and Ki67 index were able to independently differentiate MCTs with worse prognosis. This distinction is particularly meaningful in selecting intermediate grade MCTs that may benefit from more aggressive local or systemic treatment.
增殖标志物常用于肥大细胞瘤的预后评估。本研究旨在比较Ki67和有丝分裂指数在同一组患有皮肤肥大细胞瘤的犬中预测生存的相对能力。对所有样本进行组织学分级、有丝分裂指数和Ki67指数检测，并通过随访问卷获取临床信息。95只犬纳入本研究，中位随访时间为1145天。组织学分级、有丝分裂指数和Ki67指数类别之间的生存时间差异显著。多变量分析显示，Ki67指数升高的犬[风险比，HR：3.0（95%CI 1.3 - 6.8）]或有丝分裂指数升高的犬[HR：2.7（95%CI 1.1 - 6.5）]因肥大细胞瘤死亡的风险相似。总之，有丝分裂指数和Ki67指数均能够独立区分预后较差的肥大细胞瘤。这种区分在选择可能受益于更积极的局部或全身治疗的中级肥大细胞瘤时尤为重要。
