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腹主动脉瘤与结直肠癌并存:治疗困境的决策分析方法

Concomitant abdominal aortic aneurysm and colorectal cancer: a decision analysis approach to a therapeutic dilemma.

作者信息

Velanovich V, Andersen C A

机构信息

Department of Surgery, Madigan Army Medical Center, Tacoma, Washington 98431.

出版信息

Ann Vasc Surg. 1991 Sep;5(5):449-55. doi: 10.1007/BF02133050.

Abstract

The therapeutic approach to a patient with concomitant abdominal aortic aneurysm and colorectal carcinoma is not clear. Decision analysis helps clarify decision options and quantify therapeutic outcomes. Variables used in decision analysis include life expectancy after resection for colorectal cancer and abdominal aortic aneurysm, rupture rate of abdominal aortic aneurysm, complications of colorectal The results support the concept that the symptomatic lesion should be treated first. When both lesions are asymptomatic and the aneurysm is 4-5 cm in diameter, it should be resected first, if the colorectal cancer has a less than 5% chance of obstruction or perforation, as is found in noncircumferential lesions. When the aneurysm is greater than 5 cm, it should be resected first if the cancer has a less than 22% chance of obstructing or perforating, as with circumferential lesions. Simultaneous resection should be considered for patients with aneurysms greater than 5 cm and cancers with a greater than 75-80% chance of obstruction or perforation, provided the dual procedures can be performed with a less than 10% operative mortality and less than 50% complication rate.

摘要

对于同时患有腹主动脉瘤和结直肠癌的患者,其治疗方法尚不明确。决策分析有助于明确决策选项并量化治疗结果。决策分析中使用的变量包括结直肠癌和腹主动脉瘤切除术后的预期寿命、腹主动脉瘤破裂率、结直肠癌的并发症。结果支持应首先治疗有症状病变的观点。当两个病变均无症状且动脉瘤直径为4 - 5厘米时,如果结直肠癌发生梗阻或穿孔的几率小于5%(如非环形病变所见),则应首先切除动脉瘤。当动脉瘤大于5厘米时,如果癌症发生梗阻或穿孔的几率小于22%(如环形病变),则应首先切除动脉瘤。对于动脉瘤大于5厘米且癌症发生梗阻或穿孔几率大于75 - 80%的患者,若双手术操作的手术死亡率低于10%且并发症发生率低于50%,则应考虑同时切除。

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