Fremuth F
Folia Biol (Praha). 1977;23(3):212-7.
Cyclic AMP has a radioprotective effect and its aministration results in a significant increase in LD50/30 values in Chinese hamsters. The efficiency of these radioprotective effects is comparable to that of such radioprotective compounds as AET and cystamine + mexamine. Cyclic GMP is responsible for significant radiosensitizing effects. Changes in radiosensitivity after administration of cyclic nucleotides are both immediate and delayed and correlate closely with dose and time of administration.
环磷酸腺苷具有辐射防护作用，给中国仓鼠注射环磷酸腺苷会使其半数致死剂量/30天（LD50/30）值显著增加。这些辐射防护作用的效果与氨乙基异硫脲（AET）和胱胺+美沙明等辐射防护化合物相当。环磷酸鸟苷具有显著的辐射增敏作用。注射环核苷酸后辐射敏感性的变化既有即时的，也有延迟的，且与给药剂量和时间密切相关。
