18例血管免疫母细胞性T细胞淋巴瘤的临床病理特征及诊断
[Clinicopathologic features and diagnosis of 18 patients with angioimmunoblastic T-cell lymphoma].
作者信息
Yuan Xiaoyu, Chen Fangping, Bi Dandong, Zhao Xielan, He Qiongqiong, Li Qun
机构信息
Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008, China.
出版信息
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Jun;34(6):523-6.
OBJECTIVE
To explore the clinical and pathologic features of angioimmunoblastic T-cell lymphoma(AITL) and provide evidence for diagnosis.
METHODS
Eighteen AITL patients (9 males and 9 females aged from 14 to 70 years) were retrospectively analyzed in Xiangya Hospital of Central South University from July 2002 to September 2007.
RESULTS
Characteristic features at the presentation of AITL included generalized lymphadenopathy, fever, splenomegaly, and skin rashes with polyclonal hyper-gammaglobulinemia and other hematological abnormalities (such as Coombs-positive hemolytic anemia), which often involved the bone marrow and had well-described histologic features. The positive rate for CXCL13 was 93.3%.
CONCLUSION
Repeated lymphadenbiopsy is helpful for AITL diagnosis. Routine histological and immunohistochemical examinations (especially including CXCL13) play significant role in the diagnosis and differential diagnosis of AITL.
目的
探讨血管免疫母细胞性T细胞淋巴瘤（AITL）的临床及病理特征，为诊断提供依据。
方法
回顾性分析2002年7月至2007年9月在中南大学湘雅医院收治的18例AITL患者（男9例，女9例，年龄14～70岁）。
结果
AITL患者就诊时的特征性表现包括全身淋巴结肿大、发热、脾肿大、皮疹伴多克隆高球蛋白血症及其他血液学异常（如抗人球蛋白试验阳性的溶血性贫血），常累及骨髓且具有明确的组织学特征。CXCL13阳性率为93.3%。
结论
重复淋巴结活检有助于AITL的诊断。常规组织学及免疫组化检查（尤其是包括CXCL13）在AITL的诊断及鉴别诊断中起重要作用。
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