Wang Shu-Hong, Wang Quan-Shun, Sun Lu, Li Hong-Hua, Zhao Yu, Jia Bo-Jun, Zhang Xiao-Ling, Yu Li
Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Oct;18(5):1208-10.
To evaluate the clinical, pathological characters and prognosis of patients with angioimmunoblastic T cell lymphoma (AITL), the clinicopathologic features, immunophenotypes, therapy and survival rate of 12 AITL patients which were confirmed by pathologic examination were retrospectively studied. The results indicated that main symptom was observed as general lymphadenopathy, however, 9 patients had fever. The diagnosis of AITL was based on lymph-node biopsy. The histopathologic characteristics of AITL showed the damage of normal lymphnode structure, the proliferation of immunoblastic cells and arborescent super vascularization. All immunophenotypes were mature peripheral T-cellular. CVP regimen was the most common chemotherapy regimen used for patients. 58% patients have a good initial response to chemotherapy. 3-year survival was 25%, with median survival time of 25 months. In conclusion, most cases of AITL display an aggressive course, therefore, the disease progresses rapidly and has unfavorable prognosis, further studies are required to improve its therapy regimen.
为评估血管免疫母细胞性T细胞淋巴瘤（AITL）患者的临床、病理特征及预后，对12例经病理检查确诊的AITL患者的临床病理特征、免疫表型、治疗及生存率进行回顾性研究。结果显示，主要症状为全身淋巴结肿大，然而，9例患者有发热。AITL的诊断基于淋巴结活检。AITL的组织病理学特征表现为正常淋巴结结构破坏、免疫母细胞增殖及树枝状血管增生。所有免疫表型均为成熟外周T细胞。CVP方案是用于患者的最常见化疗方案。58%的患者对化疗有良好的初始反应。3年生存率为25%，中位生存时间为25个月。总之，大多数AITL病例病程呈侵袭性，因此，该疾病进展迅速且预后不佳，需要进一步研究以改进其治疗方案。
