Zou Xiaoling, Li Qinxue, Shi Chunhua
Department of Endocrinology, First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Jun;34(6):563-5.
To determine the effect of alendronate on glucocorticoid-induced osteoporosis(GIO).
Thirty-five GIO patients were enrolled. Ten milligrams alendronate were prescribed daily for 6 months. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometer (DEXA) after and before the treatment.
BMD at lumbar, neck and trochanter sites of the 35 patients after the treatment was significantly increased compared with those before the treatment (P<0.05). Urine Ca/Cr level was decreased (P<0.05). There was no severe side effect.
Alendronate is effective and well tolerated for GIO.
