Guangzhou Occupational Disease Prevention and Treatment Centre, Guangzhou No. 12 Hospital, Guangzhou, People's Republic of China.
J Hum Hypertens. 2010 Feb;24(2):139-50. doi: 10.1038/jhh.2009.52. Epub 2009 Jul 9.
The Guangzhou Biobank Cohort Study (GBCS, n=30 519, age >or=50 years) was established to examine the effects of genetic and environmental influences on health problems and chronic disease development. Guangzhou is undergoing massive economic development, but from a baseline that had remained unchanged for millennia. The Cardiovascular Disease Subcohort (GBCS-CVD) consists of 2000 participants who have been intensively phenotyped including a range of surrogate markers of vascular disease, including carotid artery intima-media thickness, cerebral artery stenoses, arterial stiffness, ankle-to-brachial blood pressure index and albuminuria, as well as coagulatory and inflammatory markers. Plasma and leukocytes are stored in liquid nitrogen for future studies. Preliminary demographic data show the female volunteers are younger than the male ones, but present with greater levels of adiposity including central obesity (31 vs 16%). Women had more body fat (33 vs 24%) and associated levels of adipokines. Despite this, body mass index and hip circumferences were similar, which contrasts with Caucasian populations. Men had more physician-diagnosed vascular disease (6.1 vs 2.5%), hypertension (42 vs 34%) and hyperglycaemia (36.6 vs 29.6%) than the women, but were less insulin resistant. In men, smoking (40 vs 2%) and drinking alcohol (67 vs 50%) was more common and they also had lower energy expenditures. The genotype distributions of the 15 typed single nucleotide polymorphisms were all in Hardy-Weinberg equilibrium. This article describes the rationale and methodology for the study. Given the comprehensive characterization of demographic and psychosocial determinants and biochemistry, the study provides a unique platform for multidisciplinary collaboration in a highly dynamic setting.
广州生物银行队列研究（GBCS，n=30519，年龄≥50 岁）旨在研究遗传和环境因素对健康问题和慢性病发展的影响。广州正在经历大规模的经济发展，但从千年不变的基线开始。心血管疾病亚组（GBCS-CVD）由 2000 名参与者组成，他们进行了广泛的表型分析，包括多种血管疾病的替代标志物，包括颈动脉内膜中层厚度、脑动脉狭窄、动脉僵硬、踝臂血压指数和白蛋白尿，以及凝血和炎症标志物。血浆和白细胞储存在液氮中，以备将来研究。初步人口统计学数据显示，女性志愿者比男性志愿者年轻，但肥胖程度更高，包括中心性肥胖（31%比 16%）。女性的体脂（33%比 24%）和相关的脂肪因子水平更高。尽管如此，体重指数和臀围相似，这与白种人群不同。男性的血管疾病（6.1%比 2.5%）、高血压（42%比 34%）和高血糖（36.6%比 29.6%）比女性更常见，但胰岛素抵抗程度较低。男性吸烟（40%比 2%）和饮酒（67%比 50%）更为常见，他们的能量消耗也较低。15 个已分型单核苷酸多态性的基因型分布均符合 Hardy-Weinberg 平衡。本文描述了研究的原理和方法。鉴于对人口统计学和社会心理决定因素以及生物化学的全面描述，该研究为在高度动态环境中进行多学科合作提供了一个独特的平台。
