Meacham R B, Lipshultz L I
University of Colorado Health Sciences Center, Denver.
Curr Opin Obstet Gynecol. 1991 Oct;3(5):656-61.
Experience in the diagnosis and treatment of infertility has led to an increased understanding of the prominent role male factors play in many couples' inability to conceive. While many forms of male factor infertility are amenable to treatment, for some patients there is no corrective therapy available. For this reason, a great deal of attention has been focused on developing technologies for semen processing and sperm utilization in cases of decreased semen quality. One area of research is the development of more sophisticated methods of assessing sperm function, as well as methods of sperm preparation. Progress is also being made in the application of technologies such as intrauterine insemination and in vitro fertilization in the treatment of male factor infertility. Such developments have improved prospects for fertility among patients suffering from decreased semen quality, as well as those suffering from such disorders as ejaculatory failure and congenital vasal agenesis. Current research also offers promise for future applications such as gamete micromanipulation. This technology holds potential for improving fertility even among patients suffering from profound male factor disorders. The following is a summary of recent publications pertaining to the application of these assisted reproductive technologies in the management of male factor infertility.
在不孕不育的诊断和治疗方面的经验，使人们越来越认识到男性因素在许多夫妇无法受孕中所起的重要作用。虽然许多形式的男性因素导致的不孕不育可以接受治疗，但对一些患者来说，没有可用的矫正疗法。因此，大量注意力集中在精液质量下降情况下精液处理和精子利用技术的开发上。一个研究领域是开发更复杂的评估精子功能的方法以及精子制备方法。在将诸如宫腔内人工授精和体外受精等技术应用于男性因素不孕不育的治疗方面也取得了进展。这些进展改善了精液质量下降患者以及患有射精功能障碍和先天性输精管缺如等疾病患者的生育前景。当前的研究也为诸如配子显微操作等未来应用带来了希望。这项技术即使对患有严重男性因素疾病的患者也有提高生育能力的潜力。以下是有关这些辅助生殖技术在男性因素不孕不育管理中的应用的近期出版物的总结。
