针对接受酒精治疗的孕妇的药物干预措施。
Pharmacologic interventions for pregnant women enrolled in alcohol treatment.
作者信息
Smith Erica J, Lui Steve, Terplan Mishka
机构信息
Department of Obstetrics and Gynecology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
出版信息
Cochrane Database Syst Rev. 2009 Jul 8;2009(3):CD007361. doi: 10.1002/14651858.CD007361.pub2.
BACKGROUND
Excessive alcohol use during pregnancy has been associated with adverse maternal and neonatal effects. It is therefore important to develop and evaluate effective interventions during this important time in a woman's life. To our knowledge there have been no systematic reviews of randomised control trials (RCT) in this population.
OBJECTIVES
To evaluate the effectiveness of pharmacologic interventions in pregnant women enrolled in alcohol treatment programs for improving birth and neonatal outcomes, maternal abstinence and treatment retention.
SEARCH STRATEGY
We searched the Cochrane Drugs and Alcohol Group's Trial register (August 2008) ; MEDLINE (1.1950 to 6.2008) ; EMBASE (1.1974 - 8.2008); CINAHL (1.1982-6.2008); PsycInfo (1.1806-6.2008), and reference lists of articles.
SELECTION CRITERIA
We sought to include randomised or quasi-randomised studies comparing any pharmacologic intervention versus other pharmacologic treatment alone or in association with psychosocial treatment, placebo, non-intervention or psychosocial intervention.
DATA COLLECTION AND ANALYSIS
Two review authors independently assessed trials for inclusion in the review. Included studies were to be assessed using standardized data extraction and quality assessment forms. No suitable trials were identified.
MAIN RESULTS
The search strategy identified 793 citations. Twenty-three citations were deemed relevant for full text review; an additional ten articles were retrieved through hand searching references, for a total of thirty-three articles. Following full text review no articles met the inclusion criteria. Data extraction and assessment of methodological quality were therefore not possible.
AUTHORS' CONCLUSIONS: The review question remains unanswered as there were no randomised control trials found relevant to the topic. There is a need for high quality research to determine the effectiveness of pharmacologic interventions in pregnant women enrolled in alcohol treatment program.
背景
孕期过度饮酒与不良的母婴影响相关。因此，在女性生命中的这一重要时期开发并评估有效的干预措施很重要。据我们所知，尚未对该人群的随机对照试验进行系统评价。
目的
评估参加酒精治疗项目的孕妇使用药物干预措施对改善分娩及新生儿结局、产妇戒酒和治疗依从性的有效性。
检索策略
我们检索了Cochrane药物与酒精研究组的试验注册库（2008年8月）；MEDLINE（1950年1月至2008年6月）；EMBASE（1974年1月至2008年8月）；CINAHL（1982年1月至2008年6月）；PsycInfo（1806年1月至2008年6月）以及文章的参考文献列表。
选择标准
我们试图纳入比较任何药物干预与单独使用其他药物治疗或与心理社会治疗、安慰剂、非干预或心理社会干预联合使用的随机或半随机研究。
数据收集与分析
两位综述作者独立评估纳入综述的试验。纳入的研究将使用标准化的数据提取和质量评估表格进行评估。未识别出合适的试验。
主要结果
检索策略识别出793条引文。23条引文被认为与全文综述相关；通过手工检索参考文献又获取了另外10篇文章，共计33篇文章。全文综述后，没有文章符合纳入标准。因此无法进行数据提取和方法学质量评估。
作者结论
由于未找到与该主题相关的随机对照试验，该综述问题仍未得到解答。需要高质量的研究来确定参加酒精治疗项目的孕妇使用药物干预措施的有效性。
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