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临床困境——孕期用药

The clinical dilemma--prescribing in pregnancy.

作者信息

Ramkisson Roshelle, Campbell Margaret, Agius Mark

机构信息

Bolton, Salford and Trafford Mental Health NHS Trus, England.

出版信息

Psychiatr Danub. 2008 Mar;20(1):88-90.

PMID:18376337
Abstract

Antipsychotic prescription in pregnancy is a complex topic and raises a great deal of anxiety in professionals. There is limited data about atypical antipsychotic prescription in pregnancy and its possible teratogenicity. There are no randomised controlled studies of atypical antipsychotic use in pregnancy due to obvious reasons of ethical issues. We present two cases where a choice had to be made as to whether to prescribe Olanzapine during pregnancy, with different results.

摘要

孕期使用抗精神病药物是一个复杂的话题,会让专业人士产生诸多担忧。关于孕期使用非典型抗精神病药物及其可能的致畸性的数据有限。由于伦理问题的明显原因,目前尚无关于孕期使用非典型抗精神病药物的随机对照研究。我们呈现两个案例,在这两个案例中,都必须做出是否在孕期开具奥氮平处方的选择,结果各不相同。

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引用本文的文献

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BMC Psychiatry. 2017 Aug 29;17(1):311. doi: 10.1186/s12888-017-1475-z.
2
Teratogenicity with olanzapine.奥氮平的致畸性。
Indian J Psychol Med. 2014 Jan;36(1):91-3. doi: 10.4103/0253-7176.127266.
3
Olanzapine in pregnancy and breastfeeding: a review of data from global safety surveillance.奥氮平在妊娠期和哺乳期的应用:全球安全性监测数据综述。
BMC Pharmacol Toxicol. 2013 Aug 1;14:38. doi: 10.1186/2050-6511-14-38.
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Effect of atypical antipsychotics on fetal growth: is the placenta involved?非典型抗精神病药物对胎儿生长的影响:胎盘是否参与其中?
J Pregnancy. 2012;2012:315203. doi: 10.1155/2012/315203. Epub 2012 Jul 11.
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Pharmacologic interventions for pregnant women enrolled in alcohol treatment.针对接受酒精治疗的孕妇的药物干预措施。
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