Atkinson K, Turner J, Biggs J C, Dodds A, Concannon A
Department of Haematology, St Vincent's Hospital, Sydney, Australia.
Bone Marrow Transplant. 1991 Sep;8(3):231-4.
An acute pulmonary syndrome possibly representing acute graft-versus-host disease (GVHD) involving lung interstitium occurred in a patient given an allogeneic bone marrow transplant for haematological malignancy. He presented at day 34 with acute GVHD of skin and bowel, and this was associated with cough, dyspnoea and an asymmetrical change on chest X-ray. Lung biopsy demonstrated an interstitial and peribronchial lymphocytic infiltrate and acute bronchial epithelial degeneration. He responded symptomatically to high dose intravenous methylprednisolone. The radiological change resolved completely. This case, thought to represent GVHD involving lung interstitium, emphasizes the need for tissue procurement in the management of non-bacterial lung disease after marrow transplantation.
一名因血液系统恶性肿瘤接受异基因骨髓移植的患者发生了一种可能代表涉及肺间质的急性移植物抗宿主病（GVHD）的急性肺综合征。他在第34天出现皮肤和肠道的急性GVHD，同时伴有咳嗽、呼吸困难以及胸部X线的不对称改变。肺活检显示间质和支气管周围淋巴细胞浸润以及急性支气管上皮变性。他对大剂量静脉注射甲基强的松龙有症状性反应。放射学改变完全消退。该病例被认为代表涉及肺间质的GVHD，强调了在骨髓移植后非细菌性肺部疾病管理中进行组织取材的必要性。
