Ishizaki K, Omoto K, Sekiguchi T
Hum Genet. 1977 Jun 30;37(2):231-4. doi: 10.1007/BF00393586.
Chimpanzee-mouse hybrid cells were isolated by fusing chimpanzee HGPRT- cells and mouse TK- cells. Both biochemical and cytologic studies of these hybrid cells and BUDR resistant cells isolated from them showed that the TK and GaK genes are located on the chimpanzee chromosome 19.
通过将黑猩猩次黄嘌呤鸟嘌呤磷酸核糖转移酶缺陷型(HGPRT-)细胞与小鼠胸苷激酶缺陷型(TK-)细胞融合,分离出了黑猩猩-小鼠杂交细胞。对这些杂交细胞以及从它们中分离出的耐5-溴脱氧尿苷(BUDR)细胞进行的生化和细胞学研究均表明,胸苷激酶(TK)基因和半乳糖激酶(GaK)基因位于黑猩猩19号染色体上。