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三尖瓣置换术是灾难性手术吗?

Is tricuspid valve replacement a catastrophic operation?

机构信息

Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea.

出版信息

Eur J Cardiothorac Surg. 2009 Nov;36(5):825-9. doi: 10.1016/j.ejcts.2009.04.063. Epub 2009 Jul 8.

Abstract

OBJECTIVE

Tricuspid valve replacement (TVR) has a high postoperative mortality, despite recent advances in perioperative care. We report the results of our experience in TVR with an emphasis on early mortality and morbidity and long-term follow-up.

METHODS

Between October 1994 and August 2007, 80 consecutive TVRs were performed in 78 patients. The mean age was 48+/-14 (range: 20-70) years. The underlying disease of the patients was classified as rheumatic (n=54), congenital (n=12), endocarditis (n=10) or degenerative (n=4). Previous cardiac surgery had been performed in 40 patients (50%). Isolated TVR was performed in 24 patients (30%).

RESULTS

Hospital mortality occurred in one patient (1.4%). Postoperative morbidities included intra-aortic balloon pump (n=5), bleeding re-operation (n=4), delayed sternal closure (n=3), acute renal failure (n=3), subdural haematoma (n=3), extracorporeal membrane oxygenation (n=1), mediastinitis (n=1) and pacemaker insertion (n=4). In 42 patients, ventilator support was needed for more than 72 h. Based on multivariate analysis, age (p<0.001) and the cardiopulmonary time (p=0.004) were the identified risk factors. Follow-up was completed in all patients with a mean duration of 56+/-37 (range: 0-158) months. During the follow-up period, there were seven deaths (8.8%), including five cardiac deaths. The 5- and 8-year survival rates were 95+/-3% and 79+/-9% and event-free survival rates were 76+/-6% and 61+/-9%, respectively. Based on multivariate analysis, the only identified predictors of late deaths was a postoperative low cardiac output (p=0.024).

CONCLUSIONS

TVR can be performed and low operative mortality can be achieved thorough optimal perioperative management in the current era.

摘要

目的

尽管围手术期护理有了最近的进展,三尖瓣置换(TVR)的术后死亡率仍然很高。我们报告我们在 TVR 方面的经验结果,重点是早期死亡率和发病率以及长期随访。

方法

1994 年 10 月至 2007 年 8 月,78 例患者连续进行 80 例 TVR。平均年龄为 48±14 岁(范围:20-70 岁)。患者的基础疾病分为风湿性(n=54)、先天性(n=12)、心内膜炎(n=10)或退行性(n=4)。40 例患者(50%)之前进行过心脏手术。24 例患者(30%)进行了单纯性 TVR。

结果

1 例患者(1.4%)发生院内死亡。术后并发症包括主动脉内球囊泵(n=5)、出血再次手术(n=4)、延迟胸骨闭合(n=3)、急性肾衰竭(n=3)、硬膜下血肿(n=3)、体外膜肺氧合(n=1)、纵隔炎(n=1)和起搏器植入(n=4)。42 例患者需要呼吸机支持超过 72 小时。基于多变量分析,年龄(p<0.001)和心肺时间(p=0.004)是确定的危险因素。所有患者均完成随访,平均随访时间为 56±37 个月(范围:0-158 个月)。随访期间,有 7 例死亡(8.8%),包括 5 例心脏死亡。5 年和 8 年生存率分别为 95±3%和 79±9%,无事件生存率分别为 76±6%和 61±9%。基于多变量分析,晚期死亡的唯一确定预测因素是术后低心输出量(p=0.024)。

结论

在当前时代,通过优化围手术期管理,可以进行 TVR,并且可以实现较低的手术死亡率。

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