Alnajar Ahmed, Chatterjee Subhasis, Olive Jacqueline K, Kaymakci Mahmut S, Gray Lauren, Gray Zachary, Breda Joao R, Lamelas Joseph
Division of Cardiothoracic Surgery, DeWitt Daughtry Department of Surgery, University of Miami Miller School of Medicine, Miami, Fla.
Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex.
JTCVS Open. 2023 Dec 27;17:98-110. doi: 10.1016/j.xjon.2023.12.009. eCollection 2024 Feb.
Isolated tricuspid valve surgery is uncommon and associated with high perioperative morbidity and mortality. We aimed to study the overall outcomes of patients who underwent minimally invasive right thoracotomy tricuspid valve surgery (Mini-TVS), consisting of either tricuspid valve repair (TVre) or replacement (TVR).
We performed a retrospective analysis of all Mini-TVS procedures (2017-2022), through which we identified isolated tricuspid valve surgeries. We examined in-hospital outcomes, survival analysis over a 4-year period, and competing risk analysis for reoperative surgery.
Among a total of 51 patients, the average age was 60 ± 16 years, and 67% (n = 34) were female. Severe tricuspid regurgitation was present in all cases. Infective endocarditis was noted in 7.8% (n = 4), and 24% (n = 12) had preexisting pacemakers. Mini-TVS included TVre in 18 patients (35%) and TVR in 33 patients (65%). The in-hospital and 30-day mortality rates were 4% (n = 2) and 6% (n = 3), respectively. At 4 years, the overall TVS survival was 76% (confidence interval, 62-93%), with no significant difference between TVre and TVR (91% vs 69%, = .16). At follow-up, 3 patients required repeat surgery for recurrent regurgitation after 2.6, 3.3, and 11 months, with a reoperation rate of 7.3% (confidence interval, 2.4-22%) at 2 years. Factors associated with worse overall survival included nonelective surgery, right ventricular dysfunction, serum creatinine >2 g/dL, and concomitant left-sided valve disease.
A nonsternotomy minimally invasive approach is a feasible option for high-risk patients. Midterm outcomes were similar in repair or replacement. Patients with right ventricular dysfunction and left-sided disease had worse outcomes.
孤立性三尖瓣手术并不常见,且围手术期发病率和死亡率较高。我们旨在研究接受微创右胸壁切口三尖瓣手术(Mini-TVS)患者的总体结局,该手术包括三尖瓣修复(TVre)或置换(TVR)。
我们对所有Mini-TVS手术(2017 - 2022年)进行了回顾性分析,从中确定孤立性三尖瓣手术。我们检查了住院结局、4年期间的生存分析以及再次手术的竞争风险分析。
在总共51例患者中,平均年龄为60±16岁,67%(n = 34)为女性。所有病例均存在严重三尖瓣反流。7.8%(n = 4)的患者有感染性心内膜炎,24%(n = 12)的患者术前已安装起搏器。Mini-TVS包括18例(35%)三尖瓣修复和33例(65%)三尖瓣置换。住院死亡率和30天死亡率分别为4%(n = 2)和6%(n = 3)。4年时,三尖瓣手术总体生存率为76%(置信区间,62 - 93%),三尖瓣修复和置换之间无显著差异(91%对69%,P = 0.16)。随访时,3例患者在2.6、3.3和11个月后因复发性反流需要再次手术,2年时再次手术率为7.3%(置信区间,2.4 - 22%)。与总体生存较差相关的因素包括非择期手术、右心室功能障碍、血清肌酐>2 g/dL以及合并左侧瓣膜疾病。
对于高危患者,非胸骨切开微创方法是一种可行的选择。修复或置换的中期结局相似。右心室功能障碍和左侧疾病患者的结局较差。