Prakash M R, Norgren R
Department of Behavioral Science, College of Medicine, Pennsylvania State University, Hershey 17033.
Brain Res Bull. 1991 Sep-Oct;27(3-4):397-401. doi: 10.1016/0361-9230(91)90132-4.
To raise a natural sodium appetite in the laboratory requires approximately 10 days on a very low sodium diet. Most other regimens induce sodium appetite more rapidly, but also result in behavioral or physiological changes not observed in the deprivation-induced state. We compared the characteristics of need-free sodium appetite induced either by systemic aldosterone combined with an intracerebroventricular (ICV) injection of angiotensin II or by a single ICV injection of renin with an appetite induced by 10 days of sodium deprivation. We measured the latency to drink water and 3% NaCl, as well as the amount of these fluids consumed at 30 min, 3 h, and 24 h. Angiotensin induced the shortest latency for both water and salt drinking, but the overall salt intake was lower. In 24 h, renin and sodium deprivation both induced about 14 ml of NaCl consumption, but the time course of the fluid intake differed for the two regimens.
在实验室中引发自然的钠食欲需要在极低钠饮食下维持约10天。大多数其他方案能更快地引发钠食欲，但也会导致在剥夺诱导状态下未观察到的行为或生理变化。我们比较了通过全身注射醛固酮并脑室内（ICV）注射血管紧张素II诱导的无需求钠食欲的特征，以及通过单次ICV注射肾素诱导的食欲与10天钠剥夺诱导的食欲。我们测量了饮水和饮用3%氯化钠溶液的潜伏期，以及在30分钟、3小时和24小时时消耗的这些液体的量。血管紧张素诱导饮水和饮盐的潜伏期最短，但总体盐摄入量较低。在24小时内，肾素和钠剥夺均诱导约14毫升氯化钠的消耗，但两种方案的液体摄入时间进程不同。
