血管紧张素与BALB/c小鼠的盐食欲
Angiotensin and salt appetite of BALB/c mice.
作者信息
Denton D A, Blair-West J R, McBurnie M, Osborne P G, Tarjan E, Williams R M, Weisinger R S
机构信息
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
出版信息
Am J Physiol. 1990 Oct;259(4 Pt 2):R729-35. doi: 10.1152/ajpregu.1990.259.4.R729.
The influence of systemic or intracerebroventricular (icv) administration of angiotensin II on the intakes of NaCl solution, water, and food was investigated in BALB/c mice. Systemic administration of angiotensin II had little, if any, influence on these ingestive behaviors. On the other hand, icv infusion of angiotensin II at 70 ng/day increased (P less than 0.05) intakes of NaCl solution and water by the third day of infusion. The amount of NaCl ingested daily during the infusion was two to three times body sodium content. The mean daily water intake increased to 40-60% of body weight. The vast increase in NaCl intake was not secondary to a natriuresis caused by the icv infusion of angiotensin II. The results suggest that angiotensin II has a direct effect on neural systems involved in sodium appetite in this species.
在BALB/c小鼠中研究了全身或脑室内（icv）给予血管紧张素II对NaCl溶液、水和食物摄入量的影响。全身给予血管紧张素II对这些摄食行为几乎没有影响（如果有影响的话也很小）。另一方面，每天脑室内注入70 ng血管紧张素II，到注入的第三天时，NaCl溶液和水的摄入量增加（P<0.05）。注入期间每日摄入的NaCl量是机体钠含量的两到三倍。每日平均饮水量增加到体重的40%-60%。NaCl摄入量的大幅增加并非由脑室内注入血管紧张素II引起的利钠作用所致。结果表明，血管紧张素II对该物种中参与钠食欲的神经系统有直接作用。
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