不明尿毒症溶质（分子量低于 5 kDa）的清除在血液透析器选择中起着重要作用。

The clearance of unidentified uremic solutes (with molecular weight under 5 kDa) plays an important role in hemodialyzer selection.

机构信息

Department of Biomedical Engineering, Chung Yuan Christian University, 200, Chung Pei Rd., Chung Li 32023, Taiwan, ROC.

出版信息

Int Urol Nephrol. 2010 Jun;42(2):465-70. doi: 10.1007/s11255-009-9613-2. Epub 2009 Jul 10.

DOI:10.1007/s11255-009-9613-2

PMID:19590973

Abstract

BACKGROUND

The purpose of this study was to evaluate two commercial hemodialyzers (F100 and P21) through the clearance of identified and unidentified uremic solutes.

METHODS

We investigated plasma samples from healthy and uremic subjects.

RESULTS

We found three unidentified uremic solutes (P1, P2, and P3) after HPLC analysis of plasma samples. Then, we determined the clearance of four identified and the three unidentified uremic solutes in patients with F100 and P21. There was no significance between F100 and P21 in clearance of four identified uremic solutes. By contrast, the clearance of P1 and P2 with F100 was superior with the P21 (P < 0.05).

CONCLUSION

Our data suggest that selection of a hemodialyzer based on the clearance of identified uremic solutes might not be sufficient. Application of external techniques to determine additional external factors (i.e., clearance of unidentified uremic solutes) can facilitate a better decision in the selection of the ideal hemodialyzer.

摘要

背景

本研究旨在通过鉴定和未鉴定的尿毒症溶质的清除率来评估两种商业血液透析器（F100 和 P21）。

方法

我们研究了健康和尿毒症患者的血浆样本。

结果

通过对血浆样本进行 HPLC 分析，我们发现了三种未鉴定的尿毒症溶质（P1、P2 和 P3）。然后，我们在 F100 和 P21 患者中测定了四种鉴定和三种未鉴定尿毒症溶质的清除率。在四种鉴定尿毒症溶质的清除率方面，F100 和 P21 之间没有差异。相比之下，F100 对 P1 和 P2 的清除率优于 P21（P<0.05）。