Shen Jiwei, Ren Hongwei, Tomiyama-Miyaji Chikako, Watanabe Mayumi, Kainuma Eisuke, Inoue Masashi, Kuwano Yuh, Abo Toru
Department of Immunology, Niigata University School of Medicine, Niigata, Japan.
Cell Immunol. 2009;259(1):66-73. doi: 10.1016/j.cellimm.2009.05.015. Epub 2009 Jun 6.
Mice were exposed to starvation for 3 days. Body temperature and various parameters were examined. By starvation, body temperature, blood glucose and ACTH decreased, especially on days 2 and 3. The level of corticosterone increased at this time. On the other hand, the number of lymphocytes yielded by the liver, spleen and thymus decreased from day 1 to 3. The change of the distribution of lymphocyte subsets was unique because NK, NKT and extrathymic T cells were stress-resistant in the liver. Conventional T and B cells were stress-sensitive. Reflecting the increased proportion of NK and NKT cells, NK and NKT activities were augmented. The increased proportion of NKT cells produced both IFNgamma and IL-4 (Th0-type profile). The proportion and some functions of granulocytes and macrophages increased on Day 1 after starvation. These results suggest that starvation has a potential to increase the functions of unconventional lymphocytes and myeloid cells.
将小鼠禁食3天。检测体温及各项参数。禁食后，体温、血糖和促肾上腺皮质激素下降，尤其在第2天和第3天。此时皮质酮水平升高。另一方面，从第1天到第3天，肝脏、脾脏和胸腺产生的淋巴细胞数量减少。淋巴细胞亚群分布的变化很独特，因为自然杀伤细胞（NK）、自然杀伤T细胞（NKT）和胸腺外T细胞在肝脏中具有抗应激能力。传统的T细胞和B细胞对压力敏感。反映出NK和NKT细胞比例增加，NK和NKT活性增强。NKT细胞比例增加产生了γ干扰素（IFNγ）和白细胞介素-4（IL-4，Th0型特征）。禁食后第1天，粒细胞和巨噬细胞的比例及一些功能增加。这些结果表明，饥饿有可能增强非传统淋巴细胞和髓样细胞的功能。
