Achimaş-Cadariu P, Irimie Al, Achimaş-Cadariu L, Neagoe I, Buiga R
University of Medicine and Pharmacy "Iuliu Hatieganu" Cluj-Napoca, Institute of Oncology "Prof. Dr. Ion Chiricuta" Cluj-Napoca, Romania.
Chirurgia (Bucur). 2009 May-Jun;104(3):287-93.
The objective of this study is to assess and quantify a relationship between different categories of prognostic factors in ovarian cancer, to establish patterns that explain the aggressiveness of some tumors, as well as to consider the above mentioned issues with regard to therapy decisions.
This prospective observational and analytical research comprised 124 cases. The following were calculated: descriptive statistics, statistical comparisons, linear and multiple regressions, survival calculations, for clinical, serological, ultrasonographic, biological and temporal variables. In addition, new prognostic indexes were introduced.
A significant difference was found between well known predictors for evolution of ovarian cancer in the malignant and benign groups: Platelet Derived Endothelial Cell Growth Factor (PDECGF) p=0.0001; CA125 p=0.0027. Potential ultrasonographic and serologic predictors for malignity of ovarian masses were identified. Only two ultrasonographic predictors: Multilocular Solid Masses insight the tumor and Diastolic Notch fulfilled the required values in order to be considered independent predictors for disease free interval. High level correlation between serologic and ultrasonographic predictors was calculated; significant correlation between preoperative and postoperative vascular indexes was demonstrated.
The results suggest the possibility of therapy in ovarian cancer patients adjusted also to the angiogenic component of the disease.
本研究的目的是评估和量化卵巢癌不同类别预后因素之间的关系，建立能够解释某些肿瘤侵袭性的模式，并在治疗决策方面考虑上述问题。
这项前瞻性观察性和分析性研究纳入了124例病例。对临床、血清学、超声、生物学和时间变量进行了描述性统计、统计比较、线性和多元回归、生存计算。此外，还引入了新的预后指标。
在恶性和良性组中，卵巢癌进展的已知预测因素之间存在显著差异：血小板衍生内皮细胞生长因子（PDECGF）p = 0.0001；CA125 p = 0.0027。确定了卵巢肿块恶性的潜在超声和血清学预测因素。只有两个超声预测因素：肿瘤内多房实性肿块和舒张期切迹满足所需值，才能被视为无病间期的独立预测因素。计算了血清学和超声预测因素之间的高度相关性；术前和术后血管指数之间存在显著相关性。
结果表明，卵巢癌患者的治疗有可能也根据疾病的血管生成成分进行调整。
