Origin of chromosome rearrangements in two long-lived human keratinocyte lines.
作者信息
Rosenberg C, Stetten G, Kearns W G, Pearson P L, Littlefield J W
机构信息
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
出版信息
In Vitro Cell Dev Biol. 1991 Oct;27A(10):823-5. doi: 10.1007/BF02631249.
PMID:1960149
Abstract
We have determined the origin of the extra chromosomal material in the karyotypes of two spontaneously-occurring long-lived human keratinocyte lines, HKC-N2 and HKC-N6. In each case the extra material was derived from the chromosome on which it was located. Possible relationships between the triplication of chromosomal material and the overcoming of cell senescence are discussed.
摘要
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