Church Martin K, Gillard Michel, Sargentini-Maier Maria Laura, Poggesi Italo, Campbell Alison, Benedetti Margherita Strolin
Charité - Universitätsmedizini Berlin, Germany. mkc@ southampton.ac.uk
Drug Metab Rev. 2009;41(3):455-74. doi: 10.1080/10837450902891535.
Whilst pharmacokinetics describe the relationship between dose levels and concentration-time profiles of a drug in the body and pharmacodynamics describe the concentration-response relationships, pharmacokinectics-pharmacodynamics(PK-PD) models link these two items providing a framework for modelling the time course of drug response. In this chapter, PK-PD models, describing the therapeutic effects of drugs used for the therapy of allergic diseases have been reviewed. Emphasis was given also to the description of the receptor occupancy, which is tightly related to the downstream clinical response. PK - PD models describing unwanted effects were also commented. An integrated use of these models allows choosing appropriate dosing regimens and providing an objective evaluation of the benefit/risk balance.
虽然药代动力学描述了体内药物剂量水平与浓度-时间曲线之间的关系，药效学描述了浓度-反应关系，但药代动力学-药效学（PK-PD）模型将这两者联系起来，为药物反应的时间过程建模提供了一个框架。在本章中，对描述用于治疗过敏性疾病的药物治疗效果的PK-PD模型进行了综述。还重点描述了与下游临床反应密切相关的受体占有率。对描述不良反应的PK-PD模型也进行了评论。综合使用这些模型可以选择合适的给药方案，并对获益/风险平衡进行客观评估。
