Netrin与DCC：神经系统发育和癌症交叉点上的轴突导向调节因子
Netrin and DCC: axon guidance regulators at the intersection of nervous system development and cancer.
作者信息
Duman-Scheel M
机构信息
Indiana University School of Medicine-South Bend at Notre Dame, Raclin-Carmichael Hall, 1234 Notre Dame Ave., South Bend, IN 46617, USA.
出版信息
Curr Drug Targets. 2009 Jul;10(7):602-10. doi: 10.2174/138945009788680428.
Abstract
In recent years, a number of axon guidance genes, including Netrin (Net) and Deleted in Colorectal Cancer (DCC), have been implicated in human cancers. Many of the hallmarks of human cancer, such as cell growth, invasion, evasion of apoptosis, and formation of a blood supply to the tumor, involve cellular processes that are critical during nervous system development. Here, the roles of Net-DCC in the regulation of these cellular processes in tumors and developing neurons are discussed. The advantages of using Drosophila to study the function of Net-DCC and other axon guidance molecules in these cellular processes, as well as the potential for cancer therapeutics targeting Net-DCC are highlighted.
摘要
近年来，包括网蛋白（Net）和结直肠癌缺失基因（DCC）在内的一些轴突导向基因已被发现与人类癌症有关。人类癌症的许多特征，如细胞生长、侵袭、逃避凋亡以及肿瘤血管生成，都涉及到神经系统发育过程中至关重要的细胞过程。本文讨论了Net-DCC在肿瘤和发育中的神经元中对这些细胞过程的调节作用。强调了利用果蝇研究Net-DCC和其他轴突导向分子在这些细胞过程中的功能的优势，以及靶向Net-DCC的癌症治疗潜力。
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本文引用的文献
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UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans.UNC-6（网蛋白）使秀丽隐杆线虫中锚定细胞的侵袭膜定向。
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Dscam guides embryonic axons by Netrin-dependent and -independent functions.唐氏综合征细胞黏附分子（Dscam）通过依赖和不依赖网蛋白的功能引导胚胎轴突。
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UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites.UNC-6/网蛋白及其受体UNC-5在局部将突触前成分排除在树突之外。
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