Reiss Allison B, Anwar Kamran, Wirkowski Peter
Vascular Biology Institute, Department of Medicine, Winthrop-University Hospital, Suite 502, Mineola, NY 11501, USA.
Curr Med Chem. 2009;16(21):2641-52. doi: 10.2174/092986709788681994.
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is a scavenger receptor that primarily binds and regulates oxidized low-density lipoprotein (LDL). Expression of LOX-1 is regulated by a feed-forward system stimulated by oxidized LDL (oxLDL), a major component of atherosclerosis. LOX-1 is a homodimer with a reactive backbone that can bind to a host of different ligands, including small molecules, and whole cells. LOX-1 is involved in many intercellular, intracellular, and molecular processes that are atherogenic. LOX-1 levels are elevated within atherosclerotic plaques and its expression is induced by proinflammatory cytokines. The ability of LOX-1 to bind many different ligands and control several atherogenic processes makes this receptor a likely vascular disease biomarker as well as an ideal choice for drug therapy aimed at preventing cardiovascular disease.
凝集素样氧化型低密度脂蛋白受体-1（LOX-1）是一种清道夫受体，主要结合并调节氧化型低密度脂蛋白（LDL）。LOX-1的表达受氧化型LDL（oxLDL）刺激的前馈系统调节，氧化型LDL是动脉粥样硬化的主要成分。LOX-1是一种同型二聚体，具有反应性骨架，可与许多不同的配体结合，包括小分子和完整细胞。LOX-1参与许多促动脉粥样硬化的细胞间、细胞内和分子过程。LOX-1水平在动脉粥样硬化斑块内升高，其表达由促炎细胞因子诱导。LOX-1结合多种不同配体并控制多个促动脉粥样硬化过程的能力，使该受体成为可能的血管疾病生物标志物，也是旨在预防心血管疾病的药物治疗的理想选择。
