几种临床前物种和人类的血液、肝脏及肠道中的酯酶活性。
Esterase activities in the blood, liver and intestine of several preclinical species and humans.
作者信息
Berry Loren M, Wollenberg Lance, Zhao Zhiyang
机构信息
Pharmacokinetics and Drug Metabolism, Amgen, Inc., Cambridge, MA, USA.
出版信息
Drug Metab Lett. 2009 Apr;3(2):70-7. doi: 10.2174/187231209788654081.
Species and tissue differences in the activity of three major classes of esterases, carboxylesterase (CE), butyrylcholinesterase (BChE) and paraoxonase (PON), were studied. Substantial species differences in activity of these esterases were observed between the mouse, rat, dog monkey and human. Such species differences must be considered when using these preclinical species to optimize the pharmacokinetic properties of ester compounds intended for human use.
研究了三种主要酯酶，即羧酸酯酶（CE）、丁酰胆碱酯酶（BChE）和对氧磷酶（PON）活性的物种和组织差异。在小鼠、大鼠、狗、猴和人类之间观察到这些酯酶活性存在显著的物种差异。在使用这些临床前物种来优化供人类使用的酯类化合物的药代动力学特性时，必须考虑这种物种差异。
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