环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的细胞外排——一个关于选择性的问题。
Cellular efflux of cAMP and cGMP - a question about selectivity.
作者信息
Sager Georg, Ravna Aina Westrheim
机构信息
Faculty of Medicine, Institute of Medical Biology, Department of Pharmacology, University of Tromsø, N- 9037 Tromsø, Norway.
出版信息
Mini Rev Med Chem. 2009 Jul;9(8):1009-13. doi: 10.2174/138955709788681654.
PMID:19601896
Abstract
The present paper reviews and discusses selectivity of ABCC4 (MRP4), ABCC5 (MRP5) and ABCC11 (MRP8) as cellular efflux pumps for cAMP and cGMP. These transporters are potential drug targets for selective modulation of cyclic nucleotide action.
摘要
本文综述并讨论了ABCC4（多药耐药相关蛋白4，MRP4）、ABCC5（多药耐药相关蛋白5，MRP5）和ABCC11（多药耐药相关蛋白8，MRP8）作为环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）细胞外排泵的选择性。这些转运蛋白是选择性调节环核苷酸作用的潜在药物靶点。
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