Fang Jia-You, Huang Zih-Rou
Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan.
Curr Drug Deliv. 2009 Jul;6(3):227-37. doi: 10.2174/156720109788680868.
The standard treatment for patients with bladder cancer is surgical transurethral resection (TUR). Intravesical chemotherapy and immunotherapy are widely used after TUR to prevent recurrence and progression of superficial disease. There are many drug therapies for bladder cancer via intravesical instillation. This review describes the drugs which are approved or currently tested for treating bladder cancers. Some new chemotherapies and immunotherapies under investigation are also introduced. Vehicles to carry or encapsulate intravesical drugs are introduced in this review. Enhancement approaches to promote drug absorption or prolong residence times such as nano-sized particles, thermo-chemotherapy, and electromotive drug administration are also discussed. This review summarizes the information regarding intravesical therapy and its enhancement techniques. Recent developments of these drugs and their carriers for in vivo or clinical use are presented.
膀胱癌患者的标准治疗方法是经尿道手术切除（TUR）。经尿道膀胱肿瘤电切术后广泛应用膀胱内化疗和免疫疗法，以预防浅表性疾病的复发和进展。通过膀胱内灌注有许多治疗膀胱癌的药物疗法。本综述描述了已获批准或目前正在试验用于治疗膀胱癌的药物。还介绍了一些正在研究的新型化疗和免疫疗法。本综述介绍了用于携带或包裹膀胱内药物的载体。还讨论了促进药物吸收或延长停留时间的增强方法，如纳米颗粒、热化疗和电动药物给药。本综述总结了有关膀胱内治疗及其增强技术的信息。介绍了这些药物及其载体在体内或临床应用方面的最新进展。
