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发情周期影响雌性小鼠下丘脑和边缘系统中神经元型一氧化氮合酶的表达。

Estrous cycle influences the expression of neuronal nitric oxide synthase in the hypothalamus and limbic system of female mice.

作者信息

Sica Monica, Martini Mariangela, Viglietti-Panzica Carla, Panzica GianCarlo

机构信息

University of Torino, Department of Anatomy, Pharmacology and Forensic Medicine, Neuroscience Institute of Turin (NIT), Laboratory of Neuroendocrinology, Torino, Italy.

出版信息

BMC Neurosci. 2009 Jul 15;10:78. doi: 10.1186/1471-2202-10-78.

DOI:10.1186/1471-2202-10-78
PMID:19604366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2717099/
Abstract

BACKGROUND

Nitric oxide plays an important role in the regulation of male and female sexual behavior in rodents, and the expression of the nitric oxide synthase (NOS) is influenced by testosterone in the male rat, and by estrogens in the female. We have here quantitatively investigated the distribution of nNOS immunoreactive (ir) neurons in the limbic hypothalamic region of intact female mice sacrificed during different phases of estrous cycle.

RESULTS

Changes were observed in the medial preoptic area (MPA) (significantly higher number in estrus) and in the arcuate nucleus (Arc) (significantly higher number in proestrus). In the ventrolateral part of the ventromedial nucleus (VMHvl) and in the bed nucleus of the stria terminalis (BST) no significant changes have been observed. In addition, by comparing males and females, we observed a stable sex dimorphism (males have a higher number of nNOS-ir cells in comparison to almost all the different phases of the estrous cycle) in the VMHvl and in the BST (when considering only the less intensely stained elements). In the MPA and in the Arc sex differences were detected only comparing some phases of the cycle.

CONCLUSION

These data demonstrate that, in mice, the expression of nNOS in some hypothalamic regions involved in the control of reproduction and characterized by a large number of estrogen receptors is under the control of gonadal hormones and may vary according to the rapid variations of hormonal levels that take place during the estrous cycle.

摘要

背景

一氧化氮在调节啮齿动物的雄性和雌性性行为中起重要作用，一氧化氮合酶（NOS）的表达在雄性大鼠中受睾酮影响，在雌性中受雌激素影响。我们在此定量研究了在发情周期不同阶段处死的完整雌性小鼠边缘下丘脑区域中nNOS免疫反应性（ir）神经元的分布。

结果

在内侧视前区（MPA）（发情期数量显著增加）和弓状核（Arc）（动情前期数量显著增加）观察到变化。在腹内侧核腹外侧部分（VMHvl）和终纹床核（BST）未观察到显著变化。此外，通过比较雄性和雌性，我们在VMHvl和BST中观察到稳定的性别二态性（与发情周期几乎所有不同阶段相比，雄性nNOS-ir细胞数量更多）（仅考虑染色较浅的细胞）。在MPA和Arc中，仅在比较周期的某些阶段时检测到性别差异。

结论

这些数据表明，在小鼠中，参与生殖控制且具有大量雌激素受体的一些下丘脑区域中nNOS的表达受性腺激素控制，并且可能根据发情周期中发生的激素水平快速变化而变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/798ae2a5868b/1471-2202-10-78-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/f53e2001bd9e/1471-2202-10-78-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/48613a25f004/1471-2202-10-78-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/2e6d88804504/1471-2202-10-78-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/ab40677d006f/1471-2202-10-78-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/cad63a143f2b/1471-2202-10-78-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/95c9723d8f58/1471-2202-10-78-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/798ae2a5868b/1471-2202-10-78-7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/f53e2001bd9e/1471-2202-10-78-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/48613a25f004/1471-2202-10-78-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/2e6d88804504/1471-2202-10-78-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/ab40677d006f/1471-2202-10-78-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/cad63a143f2b/1471-2202-10-78-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/95c9723d8f58/1471-2202-10-78-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97a5/2717099/798ae2a5868b/1471-2202-10-78-7.jpg

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