Hiramatsu Y, Sakakibara Y, Mitsui T, Hori M, Sakai A, Oosawa M
Department of Surgery, University of Tsukuba Hospital, Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1991 Oct;39(10):1945-8.
Five cases of hypernatremic hyperosmolar delirium after open heart surgery were reviewed. Minimum serum osmolarity at the time of developing delirium in these cases was 336 mOsm/l. Blood glucose level did not reached to the levels of the typical criteria of hyperosmolar hyperglycemic nonketotic diabetic coma in all cases. The authors have shown that it was difficult to recognize this unique disorder in early postoperative stage. Because of its non-specific symptoms and the postoperative courses which required the patients' cares with much more dry side in water balance. In order to treat the patients with hypernatremic hyperosmolar delirium, the correction of serum osmolarity should be done very slowly, because water intoxication should be prevented. In all five cases in this paper were recovered from delirium as the time when serum natrium level and serum osmolarity were restored to the normal state. We concluded that in order to get a good prognosis of this characteristic disorder, we have shown early recognition of serum hypernatremia and hyperosmolarity state and consequently adequate treatment mentioned above are primarily important.
回顾了5例心脏直视手术后高钠性高渗性谵妄的病例。这些病例发生谵妄时的最低血清渗透压为336 mOsm/l。所有病例的血糖水平均未达到高渗性高血糖非酮症糖尿病昏迷的典型标准水平。作者表明,在术后早期阶段很难识别这种独特的疾病。由于其非特异性症状以及术后病程需要在水平衡方面更加关注患者的干燥情况。为了治疗高钠性高渗性谵妄患者,血清渗透压的纠正应非常缓慢,因为要防止水中毒。本文中的所有5例患者在血清钠水平和血清渗透压恢复正常时谵妄均得以恢复。我们得出结论,为了使这种特征性疾病获得良好预后,早期识别血清高钠血症和高渗状态并因此进行上述充分治疗至关重要。