Gomes T, Mamdani M M, Juurlink D N
The Institute for Clinical Evaluative Sciences, Ontario, Canada.
Clin Pharmacol Ther. 2009 Oct;86(4):383-6. doi: 10.1038/clpt.2009.127. Epub 2009 Jul 15.
In this 15-year, population-based, nested case-control study, we investigated the association between hospitalization for digoxin toxicity and recent exposure to individual macrolide antibiotics. Clarithromycin was associated with the highest risk of digoxin toxicity (adjusted odds ratio (OR) 14.8; 95% confidence interval (CI) 7.9-27.9), whereas erythromycin and azithromycin were associated with much lower risk (adjusted OR 3.7; 95% CI 1.7-7.9; and adjusted OR 3.7; 95% CI 1.1-12.5, respectively). We found no increased risk with a neutral comparator, cefuroxime (adjusted OR 0.8; 95% CI 0.2-3.4).
在这项为期15年、基于人群的巢式病例对照研究中，我们调查了地高辛中毒住院与近期使用个别大环内酯类抗生素之间的关联。克拉霉素与地高辛中毒风险最高相关（调整后的比值比（OR）为14.8；95%置信区间（CI）为7.9 - 27.9），而红霉素和阿奇霉素相关风险则低得多（调整后的OR分别为3.7；95% CI为1.7 - 7.9；以及调整后的OR为3.7；95% CI为1.1 - 12.5）。我们发现中性对照药头孢呋辛并无风险增加（调整后的OR为0.8；95% CI为0.2 - 3.4）。
