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[吸烟对在比得哥什市A. 尤拉什大学医院遗传门诊接受检查的夫妇生殖失败的影响]

[The effect of smoking on reproductive failures in couples examined in the Genetic Outpatient Clinic at Dr. A. Jurasz University Hospital in Bydgoszcz].

作者信息

Pasińska Magdalena, Przybylski Grzegorz, Haus Olga, Ludwikowski Grzegorz

机构信息

Uniwersytet Mikolaja Kopernika, CM, Bydgoszcz, Katedra i Zakład Genetyki Klinicznej.

出版信息

Med Pr. 2009;60(2):117-23.

PMID:19606743
Abstract

BACKGROUND

A lack of offspring caused by sterility of one or both partners is an increasing social problem that concerns 10-19% of couples. This percentage is even higher if we take into consideration those couples who cannot have healthy offspring in spite of being able to conceive a baby. The aim of the paper was to analyze the awareness of the effect of smoking on reproductive failures in couples with infertility or habitual abortions, and in couples experiencing miscarriages and having a child or children with congenital defects. The couples underwent cytogenetic, and in some cases, molecular analysis in the Genetic Outpatient Clinic at Dr. A. Jurasz University Hospital in Bydgoszcz.

MATERIAL AND METHODS

The studied group consisted of 201 couples. In the medical documentation analysis the following aspects were taken into consideration: the patient's age, family history, genetic determinants, infections, environmental and occupational factors, which might have caused reproductive failures in the examined couples.

RESULTS

26.4% of women admitted cigarette smoking, they most often represented the group of couples having a child born with defects; 46.8% of men admitted smoking and they most often represented the group of couples that experienced habitual abortions.

CONCLUSIONS

Although it is obvious that cigarette smoking during gestation period is extremely harmful to the mother and the fetus and may significantly contribute to reproductive failures, public awareness of this problem is still insufficient and smoking habit is unfortunately widespread among pregnant women.

摘要

背景

一方或双方伴侣不育导致的无子女现象是一个日益严重的社会问题,涉及10%至19%的夫妇。如果将那些尽管能够怀孕但无法生育健康后代的夫妇考虑在内,这个比例甚至更高。本文旨在分析吸烟对不育或习惯性流产夫妇以及经历过流产且育有一个或多个患有先天性缺陷子女的夫妇生殖失败影响的认知情况。这些夫妇在比得哥什的A. 尤拉什大学医院遗传门诊接受了细胞遗传学分析,在某些情况下还进行了分子分析。

材料与方法

研究组由201对夫妇组成。在医疗文件分析中考虑了以下方面:患者年龄、家族史、遗传决定因素、感染、环境和职业因素,这些因素可能导致了被检查夫妇的生殖失败。

结果

26.4%的女性承认吸烟,她们大多来自生育有缺陷子女的夫妇群体;46.8%的男性承认吸烟,他们大多来自经历习惯性流产的夫妇群体。

结论

尽管妊娠期吸烟对母亲和胎儿极其有害且可能显著导致生殖失败这一点显而易见,但公众对这个问题的认识仍然不足,不幸的是吸烟习惯在孕妇中仍然很普遍。

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