Tan J K L
Department of Medicine, University of Western Ontario, London, ON, Canada.
Skin Therapy Lett. 2009 Jul-Aug;14(6):4-5.
Topical products commonly used to treat acne include retinoids and antimicrobials, due to their effects on different components of pathogenesis. Accordingly, a fixed combination of adapalene 0.1% and benzoyl peroxide (BPO) 2.5% was developed (Epiduo, Galderma) and was approved by the US FDA in December 2008 for the treatment of acne. The superior efficacy of this combination was demonstrated in 2 large randomized controlled trials. This paper reviews the evidence for efficacy and tolerability of the combination of the retinoid adapalene 0.1% and BPO 2.5%, a once-daily gel formulation for the treatment of acne.
常用于治疗痤疮的局部用产品包括维甲酸类和抗菌药物，因为它们对发病机制的不同组成部分有作用。因此，开发了0.1%阿达帕林和2.5%过氧化苯甲酰（BPO）的固定组合（达芙文，高德美），并于2008年12月获得美国食品药品监督管理局批准用于治疗痤疮。这种组合的卓越疗效在两项大型随机对照试验中得到了证实。本文综述了0.1%维甲酸类药物阿达帕林和2.5%BPO组合（一种用于治疗痤疮的每日一次凝胶制剂）疗效和耐受性的证据。
