Saxman S, Nichols C R, Williams S D, Loehrer P J, Einhorn L H
Department of Medicine, Indiana University School of Medicine, Indianapolis.
J Thorac Cardiovasc Surg. 1991 Dec;102(6):913-6.
Mediastinal yolk sac tumor (endodermal sinus tumor) is an extremely rare extragonadal germ cell neoplasm that has been associated with a grave prognosis. Twenty-one male patients with mediastinal yolk sac tumor received treatment at Indiana University between 1976 and 1988. Fourteen were seen after initial diagnosis, and their disease was treated with cisplatin-based chemotherapy in association with complete surgical resection if possible. Five are currently alive and disease free (36%). Seven were referred for salvage chemotherapy after relapse of their disease. Despite aggressive chemotherapy, these patients all died; they had a median survival time of 6 months. Our experience suggests that an aggressive combined modality approach with cisplatin-based chemotherapy followed by surgical resection of residual disease is the optimal management of this tumor. New regimens need to be explored for relapse of the disease after initial chemotherapy.
纵隔卵黄囊瘤（内胚窦瘤）是一种极其罕见的性腺外生殖细胞肿瘤，预后不良。1976年至1988年间，21例纵隔卵黄囊瘤男性患者在印第安纳大学接受治疗。14例在初诊后就诊，若可能，其疾病采用以顺铂为基础的化疗联合完整手术切除进行治疗。5例目前存活且无疾病（36%）。7例在疾病复发后接受挽救性化疗。尽管进行了积极化疗，这些患者均死亡；他们的中位生存时间为6个月。我们的经验表明，采用以顺铂为基础的化疗联合手术切除残余疾病的积极综合治疗方法是该肿瘤的最佳治疗方案。对于初始化疗后疾病复发，需要探索新的治疗方案。
