Tahara A, Kohno M, Yanagi S, Itagane H, Toda I, Akioka K, Teragaki M, Yasuda M, Takeuchi K, Takeda T
First Department of Internal Medicine, Osaka City University Medical School, Japan.
Metabolism. 1991 Dec;40(12):1235-7. doi: 10.1016/0026-0495(91)90021-n.
Circulating immunoreactive endothelin (ir-ET) in the coronary sinus (CS) and the femoral artery (Ao) was measured in patients who underwent percutaneous transluminal coronary angioplasty (PTCA). Plasma ir-ET level in the CS was significantly increased from 1.6 +/- 0.8 pg/mL to 2.0 +/- 1.0 pg/mL after PTCA (P less than .05). Plasma ir-ET level in the Ao tended to increase after PTCA, but it was not significant. Plasma ir-ET level in the CS was not related to the plasma thromboglobulin level, plasma thrombin-antithrombin complex level, mean blood pressure, or heart rate. These results suggest that the increase of plasma ir-ET level in the CS may be associated with the coronary endothelial injury by PTCA.
