蛋白质功能与网络的演变：以家族为中心的方法。
The evolution of protein functions and networks: a family-centric approach.
作者信息
Dessailly Benoît H, Reid Adam J, Yeats Corin, Lees Jonathan G, Cuff Alison, Orengo Christine A
机构信息
Department of Structural and Molecular Biology, University College London, London WC1E 6BT, UK.
出版信息
Biochem Soc Trans. 2009 Aug;37(Pt 4):745-50. doi: 10.1042/BST0370745.
The study of superfamilies of protein domains using a combination of structure, sequence and function data provides insights into deep evolutionary history. In the present paper, analyses of functional diversity within such superfamilies as defined in the CATH-Gene3D resource are described. These analyses focus on structure-function relationships in very large and diverse superfamilies, and on the evolution of domain superfamily members in protein-protein complexes.
利用结构、序列和功能数据相结合的方法对蛋白质结构域超家族进行研究，有助于深入了解其进化历程。本文描述了对CATH-Gene3D资源中定义的此类超家族内功能多样性的分析。这些分析聚焦于非常大且多样的超家族中的结构-功能关系，以及蛋白质-蛋白质复合物中结构域超家族成员的进化。
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