Nilsen Lill T N, Søyland Elisabeth, Krogstad Anne L
Norwegian Radiation Protection Authority, Østerås, Norway.
Photodermatol Photoimmunol Photomed. 2009 Aug;25(4):202-8. doi: 10.1111/j.1600-0781.2009.00443.x.
BACKGROUND/PURPOSE: Psoriasis is a chronic inflammatory disease affecting about 2-3% of the population. Sun exposure has a positive effect on most lesions, but ultraviolet (UV) radiation also constitutes a carcinogenic potential. Climate therapy is frequently used to treat patients, with the consequence that they may receive high doses of UV. This paper explores UV doses to patients treated in Gran Canaria.
Patient UV doses have been estimated for 20 psoriasis patients during a 15-day climate therapy study and compared with the predetermined exposure schedule and doses reported from other studies. Estimates were based on UV measurements and the patients' diaries with information on the time spent in the sun.
On the first day of exposure, the patients received on average 5.1 standard erythema doses (SED) estimated to the skin. The average dose for the 15-day study was 166 SED (250 SED for a regular 3-week treatment period). We found no significant correlation between the reduction in psoriasis area severity index scores and UV doses.
The UV doses were higher than if they had followed the prescribed exposure schedule and also higher than those reported from other climate therapy studies. It seems beneficial to focus on following the prescribed exposure schedule.
背景/目的：银屑病是一种慢性炎症性疾病，影响着约2%-3%的人口。阳光照射对大多数皮损有积极作用，但紫外线（UV）辐射也具有致癌潜力。气候疗法常用于治疗患者，结果患者可能会接受高剂量的紫外线。本文探讨了在大加那利岛接受治疗的患者所接受的紫外线剂量。
在一项为期15天的气候疗法研究中，对20名银屑病患者的紫外线剂量进行了估算，并与预先确定的照射方案以及其他研究报告的剂量进行了比较。估算基于紫外线测量以及患者记录的在阳光下停留时间的信息。
在照射的第一天，患者皮肤平均接受了5.1个标准红斑剂量（SED）。为期15天的研究的平均剂量为166 SED（常规3周治疗期为250 SED）。我们发现银屑病面积严重程度指数评分的降低与紫外线剂量之间没有显著相关性。
紫外线剂量高于遵循规定照射方案时的剂量，也高于其他气候疗法研究报告的剂量。遵循规定的照射方案似乎是有益的。
