Department of Neurology, Hebrew University Hadassah Medical Center, Jerusalem, Israel.
Eur J Neurol. 2010 Jan;17(1):78-83. doi: 10.1111/j.1468-1331.2009.02747.x. Epub 2009 Jul 9.
Pre-treatment with cholesterol lowering drugs of the statin family may exert protective effects in patients with ischaemic stroke and subarachnoid haemorrhage but their effects are not clear in patients with intracerebral haemorrhage (ICH).
We recruited patients admitted to our University Hospital with an acute ICH and analysed pre-admission demographic variables, pre-morbid therapy, clinical and radiological prognostic markers and outcome variables including 90-day modified Rankin score and NIH stroke scale score (NIHSS).
We recruited 399 patients with ICH of which 101 (25%) were using statins. Statin users more often had vascular risk factors, had significantly lower haematoma volumes (P = 0.04) and had lower mortality rates compared with non-users (45.6% vs. 56.1%; P = 0.11). However, statin treatment did not have a statistically significant impact on mortality or functional outcome on multiple logistic regression analysis.
Treatment with statins prior to ICH failed to show a significant impact on outcome in this analysis despite lower haematoma volumes.
降脂药物他汀类药物的预处理可能对缺血性卒中和蛛网膜下腔出血患者具有保护作用，但它们在脑出血（ICH）患者中的作用尚不清楚。
我们招募了在我们大学医院就诊的急性 ICH 患者，并分析了入院前的人口统计学变量、发病前的治疗、临床和影像学预后标志物以及预后变量，包括 90 天改良 Rankin 评分和 NIH 卒中量表评分（NIHSS）。
我们共招募了 399 例 ICH 患者，其中 101 例（25%）正在服用他汀类药物。与非使用者相比，他汀类药物使用者更常伴有血管危险因素，血肿体积明显较小（P=0.04），死亡率较低（45.6% vs. 56.1%；P=0.11）。然而，他汀类药物治疗在多变量逻辑回归分析中对死亡率或功能预后没有显著影响。
尽管血肿体积较小，但在本分析中，ICH 前使用他汀类药物治疗并未显示对预后有显著影响。
