Liu Zhi-zhen, Yu Zong-yang, Ouyang Xue-nong, Dai Xi-hu, Chen Xi, Zhao Zhong-quan, Wang Wen-wu, Li Jie, Tu Hua, Ye Lei, Yan Yan
Department of Oncology, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, Fujian Province, China.
Zhong Xi Yi Jie He Xue Bao. 2009 Jul;7(7):611-5. doi: 10.3736/jcim20090703.
Recently the maintenance therapy of non-small-cell lung cancer (NSCLC) patients who completed required treatment cycles has caused widespread interests in the medical field. Traditional Chinese medicine may be a useful complement in maintenance treatment of mid-to-late stage NSCLC.
To observe the effects of Feitai Capsule, a compound traditional Chinese herbal medicine for expelling blood stasis and phlegm, on the quality of life of the NSCLC patients as a maintenance treatment.
DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: A total of 62 mid-to-late stage NSCLC patients from Fuzhou General Hospital of Nanjing Military Region were included and randomly divided into treatment group (31 cases) and control group (31 cases). Patients in the treatment group were treated with Feitai Capsule, and patients in the control group did not accept any intervention. Regular observations and follow-up were performed for patients in the two groups.
Analysis of variance, nonparametric test, and analysis of covariance were used to compare clinical features, amelioration of clinical symptoms, physical constitution and energy, and quality of life.
There were two dropouts and 60 valid cases. The baseline characteristics of the two groups were similar. In the treatment group, symptom response and physical energy level were improved by 36.6% (Z=-2.632, P=0.008) and 26.7%(Z=-2.182, P=0.029), respectively. There was a positive correlation between these two factors (r=0.917, P<0.001). The patients in treatment group had a significantly improved quality of life after treatment. No serious adverse events were observed.
Feitai Capsule as maintenance treatment can improve the quality of life of the patients with mild-to-late stage NSCLC.
近期，完成规定治疗周期的非小细胞肺癌（NSCLC）患者的维持治疗引起了医学领域的广泛关注。中药可能是中晚期NSCLC维持治疗中的一种有益补充。
观察具有活血化瘀、化痰功效的复方中药肺泰胶囊对NSCLC患者维持治疗的生活质量的影响。
设计、地点、参与者和干预措施：纳入南京军区福州总医院的62例中晚期NSCLC患者，随机分为治疗组（31例）和对照组（31例）。治疗组患者服用肺泰胶囊，对照组患者不接受任何干预。对两组患者进行定期观察和随访。
采用方差分析、非参数检验和协方差分析比较临床特征、临床症状改善情况、体质和精力以及生活质量。
有2例退出，60例有效病例。两组的基线特征相似。治疗组的症状缓解率和身体能量水平分别提高了36.6%（Z=-2.632，P=0.008）和26.7%（Z=-2.182，P=0.029）。这两个因素之间存在正相关（r=0.917，P<0.001）。治疗组患者治疗后的生活质量有显著改善。未观察到严重不良事件。
肺泰胶囊作为维持治疗可提高中晚期NSCLC患者的生活质量。
