Simpson Julie H
HHMI Janelia Farm Research Campus, Asburn, VA, USA.
Adv Genet. 2009;65:79-143. doi: 10.1016/S0065-2660(09)65003-3.
Drosophila is a marvelous system to study the underlying principles that govern how neural circuits govern behaviors. The scale of the fly brain (approximately 100,000 neurons) and the complexity of the behaviors the fly can perform make it a tractable experimental model organism. In addition, 100 years and hundreds of labs have contributed to an extensive array of tools and techniques that can be used to dissect the function and organization of the fly nervous system. This review discusses both the conceptual challenges and the specific tools for a neurogenetic approach to circuit mapping in Drosophila.
果蝇是研究神经回路如何控制行为的潜在原理的绝佳系统。果蝇大脑的规模（约10万个神经元）以及果蝇能够执行的行为的复杂性，使其成为一个易于处理的实验模式生物。此外，经过100年和数百个实验室的努力，已经形成了大量可用于剖析果蝇神经系统功能和组织的工具和技术。本文综述了果蝇神经回路图谱绘制的神经遗传学方法所面临的概念挑战和具体工具。
