Kumar Vineet, Malhotra Sanjay V
Laboratory of Synthetic Chemistry, SAIC-Frederick Inc, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
Bioorg Med Chem Lett. 2009 Aug 15;19(16):4643-6. doi: 10.1016/j.bmcl.2009.06.086. Epub 2009 Jun 25.
The anti-cancer activity and cytotoxicity of phosphonium and ammonium-based ionic liquids (ILs) have been determined for the first time via NCI's in vitro 60 human tumor cell lines. The preliminary SAR showed that the chain length of alkyl substitution on the cations plays crucial role towards anti-tumor activity and cytotoxicity of these ionic liquids. In general, phosphonium-based ILs were found to be more active and less cytotoxic as compared to ammonium ILs. Cell line data and hollow fiber study has demonstrated the potential of ILs to be developed as therapeutic agent.
首次通过美国国立癌症研究所的体外60种人类肿瘤细胞系测定了鏻基和铵基离子液体（ILs）的抗癌活性和细胞毒性。初步的构效关系研究表明，阳离子上烷基取代的链长对这些离子液体的抗肿瘤活性和细胞毒性起着关键作用。一般来说，与铵基离子液体相比，鏻基离子液体被发现具有更高的活性和更低的细胞毒性。细胞系数据和中空纤维研究证明了离子液体作为治疗剂开发的潜力。
