Gatto Dominique, Paus Didrik, Basten Antony, Mackay Charles R, Brink Robert
Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia.
Immunity. 2009 Aug 21;31(2):259-69. doi: 10.1016/j.immuni.2009.06.016. Epub 2009 Jul 16.
Humoral immunity depends on both rapid and long-term antibody production against invading pathogens. This is achieved by the generation of spatially distinct extrafollicular plasmablast and follicular germinal center (GC) B cell populations, but the signals that guide responding B cells to these alternative compartments have not been fully elucidated. Here, we show that expression of the orphan G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2, also known as GPR183) by activated B cells was essential for their movement to extrafollicular sites and induction of early plasmablast responses. Conversely, downregulation of EBI2 enabled B cells to access the center of follicles and promoted efficient GC formation. EBI2 therefore provides a previously uncharacterized dimension to B cell migration that is crucial for coordinating rapid versus long-term antibody responses.
体液免疫依赖于针对入侵病原体快速且长期的抗体产生。这是通过产生空间上不同的滤泡外浆母细胞和滤泡生发中心（GC）B细胞群体来实现的，但引导反应性B细胞进入这些不同区室的信号尚未完全阐明。在此，我们表明活化的B细胞表达孤儿G蛋白偶联受体爱泼斯坦-巴尔病毒诱导基因2（EBI2，也称为GPR183）对于其迁移至滤泡外位点及诱导早期浆母细胞反应至关重要。相反，EBI2的下调使B细胞能够进入滤泡中心并促进高效的生发中心形成。因此，EBI2为B细胞迁移提供了一个此前未被描述的维度，这对于协调快速与长期抗体反应至关重要。
