Sezen Yusuf, Baş Memduh, Demirbag Recep, Yildiz Ali, Celik Hakim, Aksoy Sahin
Harran University, Faculty of Medicine, Department of Cardiology, Sanliurfa, Turkey.
Clin Biochem. 2009 Oct;42(15):1500-3. doi: 10.1016/j.clinbiochem.2009.07.007. Epub 2009 Jul 16.
In this study we investigated N-terminal pro-brain natriuretic peptide (Nt-proBNP) levels in patients with metabolic syndrome (MetS) and its relationship between MetS components.
Thirty nine recently diagnosed MetS cases and 59 control cases were included in the present study. Left ventricular mass index (LVMI) was calculated and Nt-proBNP was determined.
Both groups were similar in terms of age and sex. Body mass index were significantly higher in MetS than non-MetS. LVMI measurements were not different between MetS and control groups (p=0.168). Nt-proBNP levels were similar in both groups (p=0.954). There was a significant correlation between Nt-proBNP and LVMI, age, serum LDL- and HDL-cholesterol levels. Nt-proBNP was independently related with age (beta=0.357, p=0.015) and LDL-cholesterol (beta=-0.255, p=0.049) in the multivariate analysis.
Nt-proBNP levels don't have a significant increase in MetS. But there was a significant relationship between Nt-proBNP levels and age and LDL-cholesterol.
在本研究中，我们调查了代谢综合征（MetS）患者的N端前脑钠肽（Nt-proBNP）水平及其与MetS各组分之间的关系。
本研究纳入了39例新诊断的MetS病例和59例对照病例。计算左心室质量指数（LVMI）并测定Nt-proBNP。
两组在年龄和性别方面相似。MetS组的体重指数显著高于非MetS组。MetS组和对照组之间的LVMI测量值无差异（p = 0.168）。两组的Nt-proBNP水平相似（p = 0.954）。Nt-proBNP与LVMI、年龄、血清低密度脂蛋白和高密度脂蛋白胆固醇水平之间存在显著相关性。在多变量分析中，Nt-proBNP与年龄（β = 0.357，p = 0.015）和低密度脂蛋白胆固醇（β = -0.255，p = 0.049）独立相关。
MetS患者的Nt-proBNP水平没有显著升高。但Nt-proBNP水平与年龄和低密度脂蛋白胆固醇之间存在显著关系。
