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抽吸、挽救、缝合与药剂:抑肽酶停用后的血液管理

Suction, salvage, sutures, and potions: blood management post-aprotinin.

作者信息

Baker Robert A

机构信息

Cardiac Surgery Research and Perfusion, Flinders Medical Centre and Flinders University, Bedford Park, South Australia, Australia.

出版信息

Semin Cardiothorac Vasc Anesth. 2009 Jun;13(2):122-6. doi: 10.1177/1089253209337159. Epub 2009 Jul 17.

DOI:10.1177/1089253209337159
PMID:19617252
Abstract

Hemostasis management of the cardiac surgical patient has changed following the withdrawal of aprotinin for use in cardiac surgical patients. The challenge to minimize blood loss and reduce exposure of cardiac surgical patients to blood products continues to grow with patients presenting being older and sicker and more complex procedures being performed. The cardiac surgery team has many options available for it to consider; although current recommendations strongly support the use of cell salvage as one process to assist in this challenge, other options need to be equally critically evaluated.

摘要

随着抑肽酶不再用于心脏手术患者,心脏手术患者的止血管理发生了变化。随着接受手术的患者年龄越来越大、病情越来越重、手术操作越来越复杂,将心脏手术患者的失血量降至最低并减少其对血制品的接触这一挑战也日益严峻。心脏外科团队有许多可供考虑的选择;尽管目前的建议强烈支持使用细胞回收作为应对这一挑战的一种方法,但其他选择也需要进行同样严格的评估。

相似文献

1
Suction, salvage, sutures, and potions: blood management post-aprotinin.抽吸、挽救、缝合与药剂:抑肽酶停用后的血液管理
Semin Cardiothorac Vasc Anesth. 2009 Jun;13(2):122-6. doi: 10.1177/1089253209337159. Epub 2009 Jul 17.
2
Lessons learned in antifibrinolytic therapy: The BART trial.抗纤溶治疗的经验教训:BART试验。
Semin Cardiothorac Vasc Anesth. 2009 Jun;13(2):127-31. doi: 10.1177/1089253209338076.
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Con: Aprotinin should not be used in cardiac surgery with cardiopulmonary bypass.
J Cardiothorac Vasc Anesth. 2007 Apr;21(2):302-4. doi: 10.1053/j.jvca.2007.01.002.
4
[Aprotinin in the control of surgical hemorrhage].[抑肽酶在控制手术出血中的应用]
Med Clin (Barc). 1996 Mar 2;106(8):307-16.
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Aprotinin and cardiac surgery.抑肽酶与心脏手术
J Thorac Cardiovasc Surg. 2008 Mar;135(3):492-4. doi: 10.1016/j.jtcvs.2007.12.025.
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Con: Aprotinin has a good efficacy and safety profile relative to other alternatives for prevention of bleeding in cardiac surgery.反对观点:相对于其他预防心脏手术出血的替代药物,抑肽酶具有良好的疗效和安全性。
Anesth Analg. 2006 Dec;103(6):1360-4. doi: 10.1213/01.ane.0000244541.78602.ee.
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Can we really believe that aprotinin is safe in congenital heart surgery?我们真的能相信抑肽酶在先天性心脏手术中是安全的吗?
Ann Thorac Surg. 2011 Mar;91(3):987-8; author reply 988. doi: 10.1016/j.athoracsur.2010.07.106.
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[Commentary on the article of Dennis T. Mangano: Aprotinin and risks in cardiac surgery].
Ann Fr Anesth Reanim. 2006 Jul;25(7):791-5. doi: 10.1016/j.annfar.2006.03.033. Epub 2006 Jul 12.
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The demise of aprotinin: our share of the blame.
J Thorac Cardiovasc Surg. 2008 Apr;135(4):729-31. doi: 10.1016/j.jtcvs.2008.02.003.
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[Aprotinin in cardiac surgery: one paper of the year or a provocation from the New England Journal of Medicine].
Ann Fr Anesth Reanim. 2006 Jul;25(7):683-5. doi: 10.1016/j.annfar.2006.07.004.

引用本文的文献

1
Cell salvage for minimising perioperative allogeneic blood transfusion.细胞回收技术用于减少围手术期异体输血。
Cochrane Database Syst Rev. 2010 Apr 14;2010(4):CD001888. doi: 10.1002/14651858.CD001888.pub4.