宫内生长迟缓儿童的生长模式及其与神经认知发育的相关性。
Growth patterns in children with intrauterine growth retardation and their correlation to neurocognitive development.
作者信息
Fattal-Valevski Aviva, Toledano-Alhadef Hagit, Leitner Yael, Geva Ronny, Eshel Rina, Harel Shaul
机构信息
Institute for Child Development and Pediatric Neurology Unit, Tel Aviv Sourasky Medical Center affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Israel.
出版信息
J Child Neurol. 2009 Jul;24(7):846-51. doi: 10.1177/0883073808331082.
The relationship between somatic growth and neurocognitive outcome was studied in a cohort of 136 children with intrauterine growth retardation. The children were followed up from birth to 9 to 10 years of age by annual measurements of growth parameters, neurodevelopmental evaluations, and IQ. The rate of catch-up for height between 1 and 2 years of age was significantly higher than the catch-up for weight (P < .001). The cognitive outcome at 9 to 10 years correlated with head circumference at all ages. The neurodevelopmental outcome at 9 to 10 years correlated with weight at all ages. Correlation with head circumference was more significant with IQ, while with weight it was stronger with the neurodevelopmental score. Height at 1 year was a significant predictor for IQ and neurodevelopmental outcome at 9 to 10 years. These findings are of distinct importance for prediction of subsequent neurodevelopmental outcome in children with intrauterine growth retardation.
在一组136名宫内生长迟缓儿童中研究了身体生长与神经认知结果之间的关系。通过每年测量生长参数、进行神经发育评估和智商测试，对这些儿童从出生到9至10岁进行随访。1至2岁时身高的追赶速度明显高于体重的追赶速度（P <.001）。9至10岁时的认知结果与各年龄段的头围相关。9至10岁时的神经发育结果与各年龄段的体重相关。与头围的相关性在智商方面更显著，而与体重的相关性在神经发育评分方面更强。1岁时的身高是9至10岁时智商和神经发育结果的重要预测指标。这些发现对于预测宫内生长迟缓儿童随后的神经发育结果具有独特的重要性。
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