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剖宫产硬膜外麻醉产妇中使用腿部包裹法与去氧肾上腺素预防低血压的比较:一项前瞻性、随机、双盲研究

Wrapping of the legs versus phenylephrine for reducing hypotension in parturients having epidural anaesthesia for caesarean section: a prospective, randomized and double-blind study.

作者信息

Bjørnestad Elin, Iversen Ole Erik, Raeder Johan

机构信息

Department of Anaesthesiology and Intensive Care, Norway.

出版信息

Eur J Anaesthesiol. 2009 Oct;26(10):842-6. doi: 10.1097/EJA.0b013e328329b028.

Abstract

BACKGROUND AND OBJECTIVE

Wrapping of the legs significantly reduces hypotension during regional anaesthesia for caesarean sections. However, most obstetric anaesthetists prefer to use vasoconstrictors for reducing hypotension. We, therefore, compared the haemodynamic effects of wrapping the legs with prophylactic, repeated doses of intravenous phenylephrine in parturients having epidural anaesthesia for elective caesarean sections.

METHOD

Forty nonlabouring women, ASA physical status I or II, were randomized either to have their legs wrapped with tight elastic bandage before initiating the epidural block (leg wrapping group) plus placebo intravenous (i.v.) injections, or to receive repeated phenylephrine boluses of 50 microg immediately and at 5 and 10 min after the epidural block (phenylephrine group) combined with a loose placebo wrapping. All parturients received 500 ml of crystalloid before and after initiation of the epidural block. Hypotension, defined as a 30% decrease from initial systolic arterial pressure (SAP) or SAP lower than 90 mmHg, was treated with 5 mg i.v. doses of ephedrine repeated after 2 min if not effective. Mild hypotension was defined as the patient requiring one dose of ephedrine 5 mg, moderate as 2 or 3 doses and severe as more than three doses of ephedrine.

RESULTS

There were no differences between the study groups in the incidence or severity of hypotension. Thirteen patients (65%) in the leg wrapping group and 14 patients (70%) in the phenylephrine group remained normotensive at all times, whereas severe hypotension was noted in one patient in each group, without further complications.

CONCLUSION

Wrapping of the legs is a nonpharmacological, prophylactic method with similar blood pressure control to repeated doses of phenylephrine during epidural anaesthesia for caesarean sections.

摘要

背景与目的

剖宫产区域麻醉期间裹腿可显著降低低血压的发生率。然而,大多数产科麻醉医生更倾向于使用血管收缩剂来降低低血压。因此,我们比较了在择期剖宫产硬膜外麻醉产妇中,裹腿与预防性重复静脉注射去氧肾上腺素的血流动力学效应。

方法

40例非临产女性,ASA身体状况分级为I或II级,随机分为两组,一组在硬膜外阻滞开始前用紧绷的弹性绷带裹腿(裹腿组)并静脉注射安慰剂,另一组在硬膜外阻滞后即刻、5分钟和10分钟分别静脉注射50微克去氧肾上腺素(去氧肾上腺素组),并使用宽松的安慰剂裹腿。所有产妇在硬膜外阻滞前后均输注500毫升晶体液。低血压定义为收缩压较初始值降低30%或收缩压低于90毫米汞柱,若无效则在2分钟后重复静脉注射5毫克麻黄碱进行治疗。轻度低血压定义为患者需要一剂5毫克麻黄碱,中度为2或3剂,重度为超过三剂麻黄碱。

结果

两组间低血压的发生率和严重程度无差异。裹腿组13例患者(65%)和去氧肾上腺素组14例患者(70%)在所有时间均保持血压正常,而每组各有1例患者出现严重低血压,无进一步并发症。

结论

裹腿是一种非药物预防性方法,在剖宫产硬膜外麻醉期间控制血压的效果与重复注射去氧肾上腺素相似。

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