约旦主要教学医院肺栓塞患者中与血栓形成倾向相关的基因变异
Thrombophilia-related genetic variations in patients with pulmonary embolism in the main teaching hospital in Jordan.
作者信息
Obeidat Nathir M, Awidi Abdallah, Sulaiman Naef A, Abu-Khader Ilham B
机构信息
Department of Internal Medicine, Critical Care and Sleep Medicine, Jordan University Hospital, Amman 11942, Jordan.
出版信息
Saudi Med J. 2009 Jul;30(7):921-5.
OBJECTIVE
To study the frequency of Factor V Leiden (FVL), prothrombin gene mutation G20210A and methylenetetrahydrofolate reductase C677T in patients with acute pulmonary embolism (PE); and to investigate whether these factors are more frequent in patients who have no obvious risk factors for venous thrombo-embolism compared to those with obvious risk factors.
METHODS
A case-control study conducted at Jordan University Hospital, Amman, Jordan during the period 2005-2007. Compared 92 patients with acute PE to 99 normal subjects. All subjects were investigated for the 3 genetically related thrombophilic factors.
RESULTS
The frequency of these factors in patients were 22/92 (23.9%) FVL, 3/92 (3.3%) Factor II (FII) and 48/92 (52.2%) methylenetetrahydrofolate reductase (MTHFR). In the control group, FVL was 12/99 (12.1%), FII 0/99 (0%), and 53/99 (53.5%) MTHFR. There was a statistically significant difference between patients and controls for FVL (p=0.03), but no statistical significance for FII (p=0.10) and MTHFR (p=0.85). In patients with no obvious risk factors, the frequency of these factors were 8/29 (27.6%) FVL, 2/29 (6.9%) FII, and 14/29 (48.3%) for MTHFR compared to patients with obvious risk factors 14/63 (22.2%) for FVL, 1/63 (1.6%) FII, and 33/63 (52.3%) MTHFR.
CONCLUSION
The FVL is statistically more frequent in patients with PE compared to the control group, and the frequency of FVL, FII, and MTHFR is not significantly higher in patients with acute PE who have no obvious risk factors compared to those with obvious risk factors.
目的
研究急性肺栓塞（PE）患者中凝血因子V莱顿突变（FVL）、凝血酶原基因突变G20210A和亚甲基四氢叶酸还原酶C677T的发生频率；并调查与有明显静脉血栓栓塞危险因素的患者相比，这些因素在无明显静脉血栓栓塞危险因素的患者中是否更常见。
方法
2005年至2007年期间在约旦安曼的约旦大学医院进行了一项病例对照研究。将92例急性PE患者与99例正常受试者进行比较。对所有受试者进行了3种与遗传相关的易栓因素检测。
结果
这些因素在患者中的发生频率分别为：FVL为22/92（23.9%），凝血因子II（FII）为3/92（3.3%），亚甲基四氢叶酸还原酶（MTHFR）为48/92（52.2%）。在对照组中，FVL为12/99（12.1%），FII为0/99（0%），MTHFR为53/99（53.5%）。患者与对照组之间FVL差异有统计学意义（p = 0.03），但FII（p = 0.10）和MTHFR（p = 0.85）差异无统计学意义。在无明显危险因素的患者中，这些因素的发生频率分别为：FVL为8/29（27.6%），FII为2/29（6.9%），MTHFR为14/29（48.3%）；相比之下，有明显危险因素的患者中，FVL为14/63（22.2%），FII为1/63（1.6%），MTHFR为33/63（52.3%）。
结论
与对照组相比，PE患者中FVL在统计学上更为常见，且与有明显危险因素的急性PE患者相比，无明显危险因素的急性PE患者中FVL、FII和MTHFR的发生频率并未显著更高。
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