Huang Jian, Sun Jing, Li Wen-Xian, Wang Li-Juan, Wang An-Xu, Huo Jun-Sheng, Chen Jun-Shi, Chen Chun-Ming
Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Biomed Environ Sci. 2009 Apr;22(2):118-21. doi: 10.1016/S0895-3988(09)60033-7.
To observe the different impacts of electrolytic iron, FeSO4, and NaFeEDTA on body iron store of anemic school students.
Four hundreds anemic students at the age of 11-18 years were divided into four groups. Of which, three consumed different iron fortificants from wheat flour as food vehicle for six months and one consumed non-fortified flour (control). The fortification level of electrolytic iron, FeSO4, and NaFeEDTA was 60 mg Fe/kg, 30 mg Fe/kg, and 20 mg Fe/kg, respectively. Blood samples were collected at 0, 2, 4, and 6 months and hemoglobin (Hb), serum ferritin (SF), and transferrin receptor (TfR) were measured.
The hemoglobin levels in three intervention groups increased, the increments of Hb in the NaFeEDTA group were significantly higher than that in the other groups. SF and TfR levels increased in the tested groups and body iron store in the NaFeEDTA group was higher than that in the other groups. These parameters did not show any significant changes in the control group.
NaFeEDTA and FeSO4 fortified wheat flour has positive impacts on iron status in anemic students and NaFeEDTA is more effective than FeSO4, while electrolytic iron is less effective in improving iron store in anemic students.
观察电解铁、硫酸亚铁和乙二胺四乙酸铁钠对贫血学生机体铁储备的不同影响。
将400名11至18岁的贫血学生分为四组。其中三组食用添加不同铁强化剂的小麦粉作为食物载体，持续六个月，另一组食用未强化的面粉（对照组）。电解铁、硫酸亚铁和乙二胺四乙酸铁钠的强化水平分别为60毫克铁/千克、30毫克铁/千克和20毫克铁/千克。在第0、2、4和6个月采集血样，检测血红蛋白（Hb）、血清铁蛋白（SF）和转铁蛋白受体（TfR）。
三个干预组的血红蛋白水平均升高，乙二胺四乙酸铁钠组的Hb增量显著高于其他组。检测组的SF和TfR水平升高，乙二胺四乙酸铁钠组的机体铁储备高于其他组。对照组的这些参数未显示任何显著变化。
乙二胺四乙酸铁钠和硫酸亚铁强化小麦粉对贫血学生的铁状况有积极影响，且乙二胺四乙酸铁钠比硫酸亚铁更有效，而电解铁在改善贫血学生铁储备方面效果较差。
